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首页- Products - Others - Other Targets - Dexamethasone Phosphate disodium

Dexamethasone Phosphate disodium

CAS No. 2392-39-4

Dexamethasone Phosphate disodium ( EGP-437 | EGP 437 | EGP437. Dex-Phos )

产品货号. M26007 CAS No. 2392-39-4

地塞米松磷酸二钠是合成糖皮质激素地塞米松的水溶性形式。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG ¥332 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Dexamethasone Phosphate disodium
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    地塞米松磷酸二钠是合成糖皮质激素地塞米松的水溶性形式。
  • 产品描述
    Dexamethasone disodium phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone.(In Vitro):Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release.(In Vivo):Treatment with Dexamethasone at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water). Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    EGP-437 | EGP 437 | EGP437. Dex-Phos
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    MRGPRX1
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2392-39-4
  • 分子量
    516.41
  • 分子式
    C22H28FNa2O8P
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?H2O : ≥ 100 mg/mL (193.65 mM))
  • SMILES
    [Na+].[Na+].C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP([O-])([O-])=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62(18):8631-8641.
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